Download BioPlex Protein-Protein Interaction Data
Citations for the below data, please cite appropriately.
Select a dataset to download and view interactions
Dataset | Cell line | Description | # Baits | # Interactions | Reference |
---|---|---|---|---|---|
BioPlex 1.0 Interactions (293T Cells) | HEK293T | Summary of protein interactions in the BioPlex 1.0 Network for HEK293T cell AP-MS. | 2,594 | ~24,000 | Huttlin et al. (2015) Cell |
BioPlex 2.0 Interactions (293T Cells) | HEK293T | Summary of protein interactions in the BioPlex 2.0 Network for HEK293T cell AP-MS. | 5,891 | ~56,000 | Huttlin et al. (2017) Nature |
BioPlex 3.0 Interactions (293T Cells) | HEK293T | Summary of protein interactions in the BioPlex 3.0 Network for HEK293T cell AP-MS. | 10,128 | ~120,000 | Huttlin et al. (2020) bioRxiv |
BioPlex HCT116 v. 1.0 (HCT116 Cells) | HCT116 | Summary of protein interactions in the BioPlex 3.0 Network for HCT116 cell AP-MS. | 5,522 | ~71,000 | Huttlin et al. (2020) bioRxiv |
Download the original BioPlex viewer.
To use this browser you will need the Wolfram Player or a valid Mathematica license.
Wolfram Player: https://www.wolfram.com/player/Browswer Version | Description | Reference |
---|---|---|
BioPlex 1.0 | CDF viewer to explore HEK293T BioPlex 1.0 interactome | Huttlin et al. (2015) Cell |
Download unfiltered BioPlex protein-protein interaction data
Select a dataset to download and view candidate interactions prior to filtering to remove background
Dataset | Description | Reference |
---|---|---|
BioPlex 2.0 Unfiltered Interaction List | Summary of all potential interactions in the BioPlex 2.0 Network. WARNING: this list has not been filtered to remove background and nonspecific interactors. Use with caution. | Huttlin et al. (2017) Nature |
BioPlex 3.0 Unfiltered Interaction List | Summary of all potential interactions in the BioPlex 3.0 Network (293T Cells). WARNING: this list has not been filtered to remove background and nonspecific interactors. Use with caution. | Huttlin et al. (2020) bioRxiv |
BioPlex HCT116 1.0 Unfiltered Interaction List | Summary of all potential interactions in the BioPlex HCT116 1.0 Network (HCT116 Cells). WARNING: this list has not been filtered to remove background and nonspecific interactors. Use with caution. | Huttlin et al. (2020) bioRxiv |
* Note: the files in this table HAVE NOT been filtered to remove non-specific interacting proteins and background.
Quarterly updates - U24
Year | Quarter | Date | Cell Line | First-pass baits |
---|---|---|---|---|
1 | Q1 | 11/15/2018 | HCT116 | 405 |
1 | Q2 | 3/1/2019 | HCT116 | 399 |
1 | Q3 | 5/1/2019 | HCT116 | 400 |
1 | Q4 | 8/1/2019 | HCT116 | 391 |
2 | Q1 | 11/1/2019 | HCT116 | 404 |
2 | Q2 | 2/1/2020 | HCT116 | 410 |
2 | Q3 | 5/1/2020 | HCT116 | 405 |
NOTE: This unpublished data is provided as a resource to enable researchers to obtain information on individual proteins. With proper attribution, we highly encourage publication of targeted biological studies that follow up on individual complexes and interactions. However, we request that users refrain from publishing large-scale analysis or data mining studies using this data until we have published its contents in a peer-reviewed journal.
Quarterly updates - U41
Year | Quarter | Date | First-pass baits |
---|---|---|---|
1 | Q1 | 12/01/2015 | 362 |
1 | Q2 | 05/01/2016 | 298 |
1 | Q3 | 08/01/2016 | 325 |
1 | Q4 | 12/01/2016 | 299 |
2 | Q2 | 4/01/2017 | 298 |
2 | Q3 | 10/31/2017 | 275 |